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2013 1
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Page 1
ENPP1 Immunobiology as a Therapeutic Target.
Ruiz-Fernández de Córdoba B, Martínez-Monge R, Lecanda F. Ruiz-Fernández de Córdoba B, et al. Clin Cancer Res. 2023 Jun 13;29(12):2184-2193. doi: 10.1158/1078-0432.CCR-22-1681. Clin Cancer Res. 2023. PMID: 36719675 Free PMC article. Review.
ENPP1 promotes an immunosuppressive tumor microenvironment (TME) by tilting the balance of ATP/adenosine (Ado) in conjunction with other components (CD38, CD39/ENTPD1, and CD73/NT5E). ...Thus, ENPP1 blockade emerges as a unique target eliciting immune remodel …
ENPP1 promotes an immunosuppressive tumor microenvironment (TME) by tilting the balance of ATP/adenosine (Ado) in conjunction with ot …
Purine Release, Metabolism, and Signaling in the Inflammatory Response.
Linden J, Koch-Nolte F, Dahl G. Linden J, et al. Annu Rev Immunol. 2019 Apr 26;37:325-347. doi: 10.1146/annurev-immunol-051116-052406. Epub 2019 Jan 24. Annu Rev Immunol. 2019. PMID: 30676821 Review.
This review focuses on recent advances in our understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, ENPP1, and ENPP2/autotaxin), and signaling by key P2 purinergic receptors (P2X7, P2Y2, and P2Y12). ...
This review focuses on recent advances in our understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, …
The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy.
Stagg J, Golden E, Wennerberg E, Demaria S. Stagg J, et al. Sci Immunol. 2023 Jul 14;8(85):eabq3015. doi: 10.1126/sciimmunol.abq3015. Epub 2023 Jul 7. Sci Immunol. 2023. PMID: 37418547 Free PMC article. Review.
The pro-inflammatory nucleotides adenosine triphosphate, nicotinamide adenine dinucleotide, and cyclic guanosine -monophosphate-AMP (cGAMP), which are produced in the tumor microenvironment (TME) during therapy-induced immunogenic cell death and activation of innate immune signal …
The pro-inflammatory nucleotides adenosine triphosphate, nicotinamide adenine dinucleotide, and cyclic guanosine -monophosphate-AMP (cGAMP), …
The new insight into extracellular NAD(+) degradation-the contribution of CD38 and CD73 in calcific aortic valve disease.
Jablonska P, Kutryb-Zajac B, Mierzejewska P, Jasztal A, Bocian B, Lango R, Rogowski J, Chlopicki S, Smolenski RT, Slominska EM. Jablonska P, et al. J Cell Mol Med. 2021 Jul;25(13):5884-5898. doi: 10.1111/jcmm.15912. Epub 2021 Jun 18. J Cell Mol Med. 2021. PMID: 34142751 Free PMC article.
In stenotic valves (n = 50), due to reduced CD73 activity, NAD(+) was degraded predominantly by CD38 and additionally by ALP and eNPP1. CAVD patients had significantly higher hydrolytic rates of NAD(+) (0.81 0.07 vs 0.56 0.10) and NMN (1.12 0.10 vs 0.71 0.08 nmol/mi …
In stenotic valves (n = 50), due to reduced CD73 activity, NAD(+) was degraded predominantly by CD38 and additionally by ALP and e …
Extracellular metabolism of the enteric inhibitory neurotransmitter β-nicotinamide adenine dinucleotide (β-NAD) in the murine colon.
Durnin L, Kurahashi M, Sanders KM, Mutafova-Yambolieva VN. Durnin L, et al. J Physiol. 2020 Oct;598(20):4509-4521. doi: 10.1113/JP280051. Epub 2020 Aug 13. J Physiol. 2020. PMID: 32735345 Free PMC article.
Measuring metabolism of 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis and in SMCs, ICC and PDGFRalpha(+) cells with HPLC-FLD, we report that (1) in tissues, eNAD is degraded to eADP-ribose, eAMP and e-adenosine (eADO) by CD38, ENPP1 and NT5E, (2) with SMCs …
Measuring metabolism of 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis and in SMCs, ICC and PDGFRalpha(+) cells with HPLC-FLD, we re …
Induction of antiinflammatory purinergic signaling in activated human iNKT cells.
Yu JC, Lin G, Field JJ, Linden J. Yu JC, et al. JCI Insight. 2018 Sep 6;3(17):e91954. doi: 10.1172/jci.insight.91954. eCollection 2018 Sep 6. JCI Insight. 2018. PMID: 30185656 Free PMC article.
We also investigated the effects of stimulating cultured human iNKT cells on the expression of genes involved in the regulation of purinergic signaling. iNKT cell stimulation caused induction of ADORA2A, P2RX7, CD38, CD39, ENPP1, CD73, PANX1, and ENT1. Transcription …
We also investigated the effects of stimulating cultured human iNKT cells on the expression of genes involved in the regulation of purinergi …
Contribution of adenosine-producing ectoenzymes to the mechanisms underlying the mitigation of maternal-fetal conflicts.
Cecati M, Emanuelli M, Giannubilo SR, Quarona V, Senetta R, Malavasi F, Tranquilli AL, Saccucci F. Cecati M, et al. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2):519-29. J Biol Regul Homeost Agents. 2013. PMID: 23830401
The study included the evaluation of the expression of TNF-alpha (a pro-inflammatory cytokine) and of an alternative pathway of adenosine generation run by CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) and PC-1 (ectonucleotide pyrophosphatase/phosphodiesterase 1, …
The study included the evaluation of the expression of TNF-alpha (a pro-inflammatory cytokine) and of an alternative pathway of adenosine ge …